Population genetic structure and natural selection of Plasmodium falciparum apical membrane antigen-1 in Myanmar isolates
نویسندگان
چکیده
منابع مشابه
Analysis of Plasmodium vivax Apical Membrane Antigen-1 (PvAMA-1) Haplotypes among Iranian Isolates
Plasmodium vivax apical membrane antigen-1(PvAMA-1) is a surface protein with polymorphic sites. This study was aimed to analyze the polymorphic amino acid residues at PvAMA-1 in different infected age groups. 92 blood samples were collected from south and southeast of Iran. The DNA coding for the domain I (DI), DII, and partial DIII of this antigen was amplified by Nested-PCR, and sequenced. N...
متن کاملGenetic diversity and effect of natural selection at apical membrane antigen-1 (AMA-1) among Iranian Plasmodium vivax isolates.
Apical membrane antigen-1 (AMA-1) of Plasmodium vivax Grassi et Feletti, 1890 is a promising malaria vaccine candidate. However, antigenic variation is a major problem to design a universal malaria vaccine. Hence, detailed understanding of the pvama-1 gene polymorphism can provide conductive information on this potential vaccine component. Therefore, this study investigated the extent of geneti...
متن کاملgenetic variation and selection of domain i of the plasmodium vivax apical membrane antigen-1(ama-1) gene in clinical isolates from iran.
background: apical membrane antigen 1 (ama-1) is positioned on the surface of merozoite and it may play a role in attack to red blood cells. the mainaim of present study was to determine the genetic variation, as well as, to detect of selection at domain i of ama-1 gene plasmodium vivax isolates in iran. methods: blood samples were collected from 58 patients positive for p. vivax ,mono infectio...
متن کاملStrong diversifying selection on domains of the Plasmodium falciparum apical membrane antigen 1 gene.
The surface-accessible ectodomain region of the Plasmodium falciparum apical membrane antigen 1 (AMA1) is a malaria vaccine candidate. The amino acid sequence may be under selection from naturally acquired immune responses, and previous analyses with a small number of allele sequences indicate a non-neutral pattern of nucleotide variation. To investigate whether there is selection to maintain p...
متن کاملGenetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population.
Plasmodium vivax apical membrane antigen 1 (PvAMA-1) is an important malaria vaccine candidate. We present the first comprehensive analysis of nucleotide diversity across the entire PvAMA-1 gene using a single population sample from Sri Lanka. In contrast to what has been observed at the AMA-1 locus of Plasmodium falciparum, the signature of diversifying selection is seen most strongly in Domai...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2018
ISSN: 1475-2875
DOI: 10.1186/s12936-018-2215-7